Human circadian phase–response curves for exercise

Source avec lien : The Journal of Physiology, 597(8) 2019. 10.1113/JP276943

L’exercice entraîne d’importants effets de déphasage circadien, mais des informations fondamentales sur ces effets sont nécessaires. L’objectif principal de la présente étude était d’établir des courbes phase-réponse (CRP) documentant la taille et la direction des déphasages par rapport au temps circadien de l’exercice.

Key points

  • Exercise elicits circadian phase‐shifting effects, but additional information is needed.
  • The phase–response curve describing the magnitude and direction of circadian rhythm phase shifts, depending on the time of the zeigeber (time cue) stimulus, is the most fundamental chronobiological tool for alleviating circadian misalignment and related morbidity.
  • Fifty‐one older and 48 young adults followed a circadian rhythms measurement protocol for up to 5.5 days, and performed 1 h of moderate treadmill exercise for 3 consecutive days at one of eight times of the day/night.
  • Temporal changes in the phase of 6‐sulphatoxymelatonin (aMT6s) were measured from evening onset, cosine acrophase, morning offset and duration of excretion. Significant phase–response curves were established for aMT6 onset and acrophase with large phase delays from 7:00 pm to 10:00 pm and large phase advances at both 7:00 am and from 1:00 pm to 4:00 pm. Delays or advances would be desired, for example, for adjustment to westward or eastward air travel, respectively.
  • Along with known synergism with bright light, the above PRCs with a second phase advance region (afternoon) could support both practical and clinical applications.

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