Source avec lien : Archives of Industrial Hygiene and Toxicology, 69(3), 9/1/2018. 10.2478/aiht-2018-69-3137
Les travailleurs de la santé qui préparent ou administrent des agents cytotoxiques courent un risque d’exposition et les risques pour la santé sont réels, même à des doses inférieures à celles appliquées chez les patients cancéreux, car aucune dose n’est théoriquement sûre. La voie d’exposition la plus courante et la plus problématique est la peau, notamment parce que les surfaces de travail peuvent rester contaminées même après le nettoyage. Cette étude pilote visait à démontrer l’importance d’un protocole efficace de décontamination de surface en déterminant la contamination de surface par trois médicaments cytotoxiques courants dans le cadre d’un service de jour en oncologie.
Healthcare workers who prepare or administer cytotoxic agents run the risk of exposure, and the risks for health are real even at doses lower than those applied in cancer patients, because, in theory, no dose is safe. The most common and problematic route of exposure is through the skin, especially as work surfaces can remain contaminated even after cleaning. This pilot study aimed to demonstrate the importance of having an effective surface decontamination protocol by determining surface contamination with cyclophosphamide, 5-fluorouracil, and paclitaxel as the most common cytotoxic drugs in an oncology day service. Samples were collected before and after drug handling and analysed with high performance liquid chromatography with diode array detection (HPLC-DAD). Of the 29 samples collected before drug handling 23 were contaminated, five of which with more than one drug. Of the 30 samples collected after drug handling 25 were contaminated, eight of which with more than one drug. The two time points did not significantly differ, which evidences a widespread contamination and ineffective cleaning. This calls for revising the cleaning protocol and handling procedure to place contamination under control as much as possible.
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