Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system

Source avec lien : Occupational and Environmental Medicine, 2021(78), . 10.1136/oemed-2021-107382

Compte tenu de l’importance de la surveillance continue du COVID-19, notre objectif était de présenter les résultats d’une courte enquête de suivi des tests de détection des anticorps du SRAS-CoV-2 effectués sur le lieu de travail chez des participants précédemment séropositifs et de décrire les associations entre les lieux de travail et la séroconversion négative.

Objectives Given the importance of continued COVID-19 surveillance, our objective was to present findings from a short follow-up survey of workforce SARS-CoV-2 antibody testing in previously seropositive participants and describe associations between work locations and negative seroconversion. Methods We conducted a follow-up cross-sectional survey on previously seropositive healthcare workers, using questionnaires and serology testing. Eligible employees previously consented to be contacted were invited by email to participate in a survey and laboratory blood draws. SAS V.9.4 was used to describe employee characteristics and seroconversion status. Binomial regression models were used to calculate unadjusted and adjusted prevalence ratios (PRs) of seronegativity. The multivariable analyses included age, gender, race/ethnicity, region of residence, work location, prior diagnosis/PCR results and days between antibody tests. Unadjusted and adjusted PRs 95% CIs and p values were reported. Results Of the 3990 employees emailed in the follow-up, 1631 completed an exposure survey and generated a blood-draw requisition form. Average time between serology testing was 4 months. Of the 955 employees with complete serology results, 79.1% were female, 53.4% were white and 46.4% resided in Long Island; 176 participants seroconverted to negative. In multivariable regression analyses adjusted for gender, race/ethnicity and region of residence, younger employees (<20–30 years), intensive care unit workers and those with no/negative prior PCR results were more likely to have negative seroconversion. Conclusions and relevance Patterns of negative seroconversion showed significant differences by sociodemographic and workplace characteristics. These results contribute information to workplace serosurveillance. Lisez l’article

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