Source avec lien : Journal of Hospital Infection, Prépublication, 7/29/2019. 10.1016/j.jhin.2019.07.016
Les surfaces proches des patients dans les hôpitaux sont reconnues comme une source d’infections nosocomiales. Ces surfaces servent de réservoirs de contamination microbienne par lesquels les agents pathogènes peuvent être transmis. La désinfection routinière des surfaces n’entraîne qu’une élimination temporelle des agents pathogènes et la recontamination se produit inévitablement peu de temps entre deux désinfections consécutives. Le but de cette étude était de tester un nouveau revêtement antimicrobien basé sur l’effet photodynamique, dans des conditions de laboratoire et ensuite dans une étude de terrain dans deux hôpitaux en conditions réelles.
Summary Background Near-patient surfaces in hospitals are recognized as a source for healthcare-acquired infections. Such surfaces act as reservoirs for microbial contamination by which pathogens can be transmitted from colonized or infected patients to susceptible patients. Routine disinfection of surfaces results only in a temporal elimination of pathogens and recontamination inevitably occurs shortly between two consecutive disinfections. Aim A novel antimicrobial coating based on the photodynamic effect was tested under laboratory conditions and subsequently in a field study in two hospitals under real life conditions. Methods Identical surfaces received a photodynamic or control coating on which the bacterial counts (CFU/cm2) were regularly assessed for up to 6 months. Findings The laboratory study revealed a reduction of several human pathogens of up to 4.0 ± 0.3 log10. The field study in near-patient environments demonstrated bacterial mean values of 6.1 ± 24.7 CFU/cm2 on all control coatings. Photodynamic coatings showed significantly lower mean value of 1.9 ± 2.8 CFU/cm2 (p < 0.001). When considering benchmarks of 2.5 CFU/cm2 or 5 CFU/cm2, the relative risk for high bacterial counts on surfaces was reduced by 48 % (odds ratio 0.38, p<0.001) or 67 % (odds ratio 0.27, p<0.001), respectively. Conclusion Photodynamic coatings provide a significant and lasting reduction of bacterial counts on near-patient surfaces, in particular for high bacterial loads and in addition to routine hygiene. The promising results of this proof-of-concept study enables next important studies by which this novel technology is correlated with the frequency of HAIs. Consultez la page de l’article