Source avec lien : Drug Delivery, 29(1). 10.1080/10717544.2021.2015482
L’aérosolthérapie est utilisée pour administrer des produits thérapeutiques médicaux directement dans les voies respiratoires afin de traiter les affections respiratoires. Une conséquence potentielle de cette forme de traitement est la libération d’aérosols fugitifs, qu’ils soient issus du patient ou médicaux, dans l’environnement et l’exposition subséquente du personnel soignant et des personnes présentes à des infections virales potentielles. Cette étude a examiné la libération de ces aérosols fugitifs au cours d’une aérosolthérapie standard sur un patient adulte simulé.
Aerosol therapy is used to deliver medical therapeutics directly to the airways to treat respiratory conditions. A potential consequence of this form of treatment is the release of fugitive aerosols, both patient derived and medical, into the environment and the subsequent exposure of caregivers and bystanders to potential viral infections. This study examined the release of these fugitive aerosols during a standard aerosol therapy to a simulated adult patient. An aerosol holding chamber and mouthpiece were connected to a representative head model and breathing simulator. A combination of laser and Schlieren imaging was used to non-invasively visualize the release and dispersion of fugitive aerosol particles. Time-varying aerosol particle number concentrations and size distributions were measured with optical particle sizers at clinically relevant positions to the simulated patient. The influence of breathing pattern, normal and distressed, supplemental air flow, at 0.2 and 6 LPM, and the addition of a bacterial filter to the exhalation port of the mouthpiece were assessed. Images showed large quantities of fugitive aerosols emitted from the unfiltered mouthpiece. The images and particle counter data show that the addition of a bacterial filter limited the release of these fugitive aerosols, with the peak fugitive aerosol concentrations decreasing by 47.3-83.3%, depending on distance from the simulated patient. The addition of a bacterial filter to the mouthpiece significantly reduces the levels of fugitive aerosols emitted during a simulated aerosol therapy, p? .05, and would greatly aid in reducing healthcare worker and bystander exposure to potentially harmful fugitive aerosols.