Prevalence of SARS-CoV-2 antibodies after one-year follow up among workers in a research institute in Japan

Source avec lien : Journal of Infection, (Prépublication). 10.1016/j.jinf.2021.10.021

Le Centre national de gériatrie et de gérontologie (NCGG) est l’un des centres nationaux de médecine avancée et spécialisée composé d’un hôpital et d’un institut de recherche situé dans la préfecture d’Aichi, au centre du Japon. En raison de son rôle dans la médecine gériatrique, le centre accepte de nombreux patients âgés, présentant un risque plus élevé de mortalité due au COVID-19. Pour étudier le taux cumulatif d’infection par le SRAS-CoV-2 chez les travailleurs du NCGG au fil du temps, nous avons conçu une étude transversale répétée pour examiner les anticorps du SRAS-CoV-2.

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, China, in late 2019, and the first identified case in Japan was in January 2020.1 Later, the number of new cases began to increase exponentially in the middle of February, leading to a nationwide spread.2,3 Since then, Japan has faced five waves of the pandemic, each bigger than the last. The National Center for Geriatrics and Gerontology (NCGG) is one of the national centers for advanced and specialized medicine composed of a hospital and a research institute located in Aichi Prefecture, central Japan. Due to its roles in geriatric medicine, the center accepts many elderly patients, with a higher risk of mortality due to COVID-19. To investigate the cumulative SARS-CoV-2 infection rate among workers in the NCGG over time, we designed a repeated cross-sectional study to examine SARS-CoV-2 antibodies. We have previously reported the results of the baseline survey, a low seroprevalence of SARS-COV-2 (0.32%) in June 2020 (after the first wave).4 In this paper, we report the results of the second survey using serum collected in June 2021(during and after the fourth wave).

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